调节性B细胞
免疫系统
免疫学
天疱疮
银屑病
B细胞
特应性皮炎
美罗华
皮肌炎
医学
生物
抗体
白细胞介素10
皮肤病科
作者
Wenming Wang,Lan Guo,Hongzhong Jin
标识
DOI:10.1016/j.molimm.2020.07.016
摘要
Although T cells are considered as the central component in immune-mediated diseases, supportive evidence has demonstrated that B cells also contribute to the progression of these diseases. B cells are divided into various subsets according to their secreted cytokines. Different B cell subsets play diverse roles in immune-mediated dermatoses. Regulatory B cells (Bregs) are defined functionally by their ability to secrete IL-10, which has been revealed to contribute to immunological tolerance. Drugs that deplete B cells, such as rituximab, are now used for the treatment of several immune-mediated dermatoses. In this review, we present and discuss the current knowledge on the roles of B cells in several immune-mediate dermatoses including psoriasis, pemphigus, bullous pemphigoid, and dermatomyositis, atopic dermatitis.
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