Intestinal Inflammation and Mucosal Barrier Function

势垒函数 炎症 免疫系统 粘液 粘蛋白 分泌物 免疫学 生物 细胞生物学 微生物学 化学 生物化学 生态学
作者
Fermín Sánchez de Medina,Isabel Romero‐Calvo,Cristina Mascaraque,Olga Martínez‐Augustin
出处
期刊:Inflammatory Bowel Diseases [Oxford University Press]
卷期号:20 (12): 2394-2404 被引量:342
标识
DOI:10.1097/mib.0000000000000204
摘要

Intestinal mucosal barrier function is the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules while preserving the ability to absorb nutrients. The central element is the epithelial layer, which physically separates the lumen and the internal milieu and is in charge of vectorial transport of ions, nutrients, and other substances. The secretion of mucus-forming mucins, sIgA, and antimicrobial peptides reinforces the mucosal barrier on the extraepithelial side, while a variety of immune cells contributes to mucosal defense in the inner side. Thus, the mucosal barrier is of physical, biochemical, and immune nature. In addition, the microbiota may be viewed as part of this system because of the mutual influence occurring between the host and the luminal microorganisms. Alteration of the mucosal barrier function with accompanying increased permeability and/or bacterial translocation has been linked with a variety of conditions, including inflammatory bowel disease. Genetic and environmental factors may converge to evoke a defective function of the barrier, which in turn may lead to overt inflammation of the intestine as a result of an exacerbated immune reaction toward the microbiota. According to this hypothesis, inflammatory bowel disease may be both precipitated and treated by either stimulation or downregulation of the different elements of the mucosal barrier, with the outcome depending on timing, the cell type affected, and other factors. In this review, we cover briefly the elements of the barrier and their involvement in functional defects and the resulting phenotype.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
王哪跑发布了新的文献求助80
刚刚
randylch完成签到,获得积分10
1秒前
个性的语山完成签到,获得积分10
1秒前
zyy完成签到 ,获得积分10
1秒前
罗曼长情雪兰关注了科研通微信公众号
2秒前
大马哥完成签到 ,获得积分10
2秒前
Kyrie完成签到,获得积分10
5秒前
昌昌完成签到,获得积分10
6秒前
不想长大完成签到 ,获得积分10
7秒前
迷你的百川完成签到,获得积分10
8秒前
曾经问玉完成签到 ,获得积分20
8秒前
免疫方舟完成签到,获得积分10
10秒前
vuig完成签到 ,获得积分10
10秒前
12秒前
liu完成签到 ,获得积分10
12秒前
研友_VZG7GZ应助科研通管家采纳,获得10
13秒前
罗_应助科研通管家采纳,获得10
13秒前
13秒前
iNk应助科研通管家采纳,获得20
13秒前
科研通AI2S应助科研通管家采纳,获得10
13秒前
CodeCraft应助科研通管家采纳,获得10
13秒前
Akim应助科研通管家采纳,获得10
13秒前
桐桐应助科研通管家采纳,获得20
13秒前
ding应助科研通管家采纳,获得10
13秒前
Leo完成签到 ,获得积分10
13秒前
乐观化蛹完成签到,获得积分20
14秒前
失眠的耳机完成签到,获得积分10
16秒前
17秒前
金闪闪发布了新的文献求助10
17秒前
搬砖的化学男完成签到 ,获得积分0
19秒前
危机的慕卉完成签到 ,获得积分10
19秒前
852应助乐观化蛹采纳,获得30
20秒前
Somnolence咩完成签到,获得积分10
20秒前
Violet完成签到,获得积分10
22秒前
22秒前
sddq完成签到,获得积分10
22秒前
金闪闪完成签到,获得积分10
22秒前
Venus完成签到,获得积分10
22秒前
25秒前
Sophie_W完成签到,获得积分10
29秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2000
Very-high-order BVD Schemes Using β-variable THINC Method 1200
BIOLOGY OF NON-CHORDATES 1000
进口的时尚——14世纪东方丝绸与意大利艺术 Imported Fashion:Oriental Silks and Italian Arts in the 14th Century 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 550
The Collected Works of Jeremy Bentham: Rights, Representation, and Reform: Nonsense upon Stilts and Other Writings on the French Revolution 320
Generative AI in Higher Education 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3357038
求助须知:如何正确求助?哪些是违规求助? 2980577
关于积分的说明 8694961
捐赠科研通 2662276
什么是DOI,文献DOI怎么找? 1457729
科研通“疑难数据库(出版商)”最低求助积分说明 674849
邀请新用户注册赠送积分活动 665865