银屑病
银屑病性关节炎
医学
肿瘤坏死因子α
关节炎
皮肤病科
白细胞介素17
免疫学
类风湿性关节炎
细胞因子
作者
Kazuhisa Furue,Takamichi Ito,Masutaka Furue
出处
期刊:Cytokine
[Elsevier]
日期:2018-08-29
卷期号:111: 182-188
被引量:67
标识
DOI:10.1016/j.cyto.2018.08.025
摘要
Psoriasis and psoriatic arthritis cause significant physical and psychological burdens for afflicted individuals. An accelerated TNF-α/IL-23/IL-17 axis is their major pathomechanism; therefore, anti-TNF-α/IL-23/IL-17 biologics are very effective for the treatment of skin and joint lesions in psoriasis and psoriatic arthritis. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-α remedies in the treatment of skin lesions. In this review, we focus on the differential efficacy of anti-TNF-α/IL-23/IL-17 biologics in psoriasis and psoriatic arthritis.
科研通智能强力驱动
Strongly Powered by AbleSci AI