IDH2型
IDH1
异柠檬酸脱氢酶
胶质瘤
基因
突变
体细胞
癌症研究
突变体
生物
遗传学
酶
生物化学
作者
Hai Yan,D. Williams Parsons,Genglin Jin,Roger E. McLendon,B. Ahmed Rasheed,Weishi Yuan,Ivan Kos,Ines Batinić‐Haberle,Siân Jones,Gregory J. Riggins,Henry S. Friedman,Allan H. Friedman,David A. Reardon,James E. Herndon,Kenneth W. Kinzler,Victor E. Velculescu,Bert Vogelstein,Darell D. Bigner
标识
DOI：10.1056/nejmoa0808710
摘要
A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gliomas (secondary glioblastomas).
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