肌病毒科
噬菌体
生物
核酸
大肠杆菌
生物物理学
细胞生物学
DNA
长椭球
蛋白质结构
功能(生物学)
结晶学
化学
遗传学
基因
生物化学
物理
经典力学
作者
Moh Lan Yap,Michael G. Rossmann
出处
期刊:Future Microbiology
[Future Medicine]
日期:2014-12-01
卷期号:9 (12): 1319-1327
被引量:134
摘要
ABSTRACT Bacteriophage T4 is the most well-studied member of Myoviridae, the most complex family of tailed phages. T4 assembly is divided into three independent pathways: the head, the tail and the long tail fibers. The prolate head encapsidates a 172 kbp concatemeric dsDNA genome. The 925 Å-long tail is surrounded by the contractile sheath and ends with a hexagonal baseplate. Six long tail fibers are attached to the baseplate's periphery and are the host cell's recognition sensors. The sheath and the baseplate undergo large conformational changes during infection. X-ray crystallography and cryo-electron microscopy have provided structural information on protein–protein and protein–nucleic acid interactions that regulate conformational changes during assembly and infection of Escherichia coli cells.
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