医学
心肌炎
扩张型心肌病
发病机制
心力衰竭
心肌病
心脏病
疾病
人口
炎症
病理
免疫学
心脏病学
内科学
重症监护医学
生物信息学
环境卫生
生物
作者
Chantal ElAmm,DeLisa Fairweather,Leslie T. Cooper
出处
期刊:Heart
[BMJ]
日期:2012-03-22
卷期号:98 (11): 835-840
被引量:132
标识
DOI:10.1136/heartjnl-2012-301686
摘要
Acute myocarditis is an inflammatory disease of the heart muscle that may progress to dilated cardiomyopathy and chronic heart failure. A number of factors including the sex hormone testosterone, components of innate immunity, and profibrotic cytokines have been identified in animal models as important pathogenic mechanisms that increase inflammation and susceptibility to chronic dilated cardiomyopathy. The clinical presentation of acute myocarditis is non-specific and mimics more common causes of heart failure and arrhythmias. Suspected myocarditis is currently confirmed using advanced non-invasive imaging and histopathologic examination of heart tissue. However, the diverse presentations of myocarditis and the lack of widely available, safe, and accurate non-invasive diagnostic tests remain major obstacles to early diagnosis and population based research. Recent advances in the understanding of disease pathogenesis described in this review should lead to more accurate diagnostic algorithms and non-invasive tests.
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