脱水
组合化学
比例(比率)
一步到位
化学
化学工程
工程类
物理
生物化学
量子力学
作者
Daniel E. Patterson,Jeremiah D. Powers,Michael P. Leblanc,Tyler Sharkey,Emily Boehler,Erwin Irdam,Martin H. Osterhout
摘要
A large-scale synthesis of denagliptin tosylate has been developed. The efficiency of the synthesis has been improved from the initially scaled route by changing the order of steps (performing a dehydration at a late stage). The key step of the synthesis is a single-step peptide coupling/dehydration, mediated by n-propanephosphonic acid cyclic anhydride. The challenges of developing this synthesis into a robust and practical manufacturing route are described.
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