TLR9型
Toll样受体9
CpG站点
内质网
DNA
细胞生物学
先天免疫系统
内体
寡核苷酸
生物
TLR4型
化学
基因
受体
信号转导
细胞内
生物化学
基因表达
DNA甲基化
作者
Eicke Latz,Alberto Visintin,Terje Espevik,Douglas T. Golenbock
出处
期刊:Journal of Endotoxin Research
[SAGE]
日期:2004-12-01
卷期号:10 (6): 406-412
被引量:32
标识
DOI:10.1179/096805104225006525
摘要
Non-methylated CpG-motifs in bacterial or viral DNA are recognized by TLR9 as foreign. The activation of TLR9 by microbial DNA or synthetic oligonucleotides based on these motifs leads to the induction of innate immune responses. We have compared the subcellular localization of fluorescent versions of TLR9 and TLR4 and found that TLR9 is expressed in the endoplasmic reticulum while TLR4 is expressed on the plasma membrane. Fluorescently tagged bacterial DNA or CpG-DNA was observed to traffic to a tubular lysosomal compartment in human pDCs. In stimulated cells, TLR9 translocated to CpG-DNA or microbial DNA containing structures in the endosome, where TLR9 binds to DNA and initiates signaling.
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