介孔二氧化硅
纳米材料
氟碳化合物
介孔材料
化学工程
胶束
化学
纳米颗粒
药物输送
材料科学
表面改性
分散性
溴化物
肺表面活性物质
高分子化学
有机化学
纳米技术
水溶液
催化作用
工程类
作者
Mingxian Huang,Lu Liu,Shige Wang,Haiyan Zhu,Dahui Wu,Zhihao Yu,Shilin Zhou
出处
期刊:Langmuir
[American Chemical Society]
日期:2017-01-04
卷期号:33 (2): 519-526
被引量:55
标识
DOI:10.1021/acs.langmuir.6b03282
摘要
Highly monodisperse, dendritic, and functionalized mesoporous silica nanospheres (MSNs) with sub-200 nm size were synthesized in a one-pot sol–gel reaction, by a dual-templating micelle system consisting of a partially fluorinated short-chain anionic fluorocarbon surfactant and cetyltrimethylammonium bromide. This kind of anionic fluorocarbon surfactant works simultaneously as a swelling agent to enlarge the pore of the MSNs, an ion-pair agent to the structure-directing silane in the preparation of amine-functionalized MSNs, and a surface tension reducing agent to make the system thermodynamically more stable for producing more uniform MSNs. The particle size and the morphology of the resultant MSNs can be fine-tuned by changing the amount of the fluorocarbon surfactant added and the ratio of the functional group containing organosilane to tetraethoxysilane. Subsequently, the as-prepared MSNs were used as base materials for the preparation of drug delivery nanomaterials through the surface grafting of a pH-sensitive drug-conjugated polymer and fluorescent nanomaterials through the embedding of europium(III) complex or the immobilization of large molecule fluorescein isothiocyanate-bovine serum albumin.
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