[Research progress on the relationship between allostatic load and depression in adolescents].

Adolescence is not only an important stage of growth and development, but also a critical period for the formation of social and psychological cognition. The increasing incidence rate of depression in adolescents has caused serious global burden of disease. Allostatic load is a comprehensive index including multiple physiological system disorders. In the key stage of brain development, allostatic load plays an important role in the occurrence and development of mental diseases. This paper summarized the evaluation methods and prevalence of adolescent allostatic load, reviewed the relationship between allostatic load and adolescent depression, and revealed the possible physiological and neurobiological mechanisms, in order to provide scientific basis for prevention and control of adolescent depression.青少年时期是生长发育的重要阶段，同时也是社会认知和心理认知形成的关键时期。青少年抑郁发病率的不断攀升，造成了严重的全球疾病负担。非稳态负荷是一项包括多个生理系统失调的综合性指标，在大脑发育关键阶段，非稳态负荷在精神疾病的发生发展中扮演着重要角色。本研究总结了青少年非稳态负荷的评价方法和流行状况，综述了非稳态负荷与青少年抑郁的关联，并揭示了潜在的生理学和神经生物学机制，以期为青少年抑郁的预防与控制提供科学依据。.