This book describes the key role played by thermally excited defects such as vortices, disclinations, dislocations, vacancies and interstitials in the physics of crystals, superfluids, superconductors, liquid crystals and polymer arrays. Geometrical aspects of statistical mechanics become particularly important when thermal fluctuations entangle or crumple extended line-like or surface-like objects in three dimensions. In the case of entangled vortices above the first-order flux lattice melting transition in hightemperature superconductors, the lines themselves are defects. A variety of theories combined with renormalization-group ideas are used to describe the delicate interplay among defects, statistical mechanics and geometry characteristic of these problems in condensed matter physics. This indispensible guide has its origins in Professor Nelson’s contributions to summer schools, conference proceedings and workshops over the past twenty years. It provides a coherent and pedagogic graduate-level introduction to the field of defects and geometry.