多巴胺
被盖腹侧区
血清素
神经科学
血清素转运体
5-羟色胺质膜转运蛋白
神经递质
再摄取
5-羟色胺能
多巴胺转运体
谷氨酸的
内科学
心理学
生物
神经传递
医学
多巴胺能
中枢神经系统
受体
作者
Catarina Cunha,John F. Smiley,Nao Chuhma,Relish Shah,Cynthia Bleiwas,Edênia da Cunha Menezes,Rebecca P. Seal,Robert H. Edwards,Stephen Rayport,Mark S. Ansorge,F. Xavier Castellanos,Cátia M. Teixeira
标识
DOI:10.1038/s41380-020-0763-z
摘要
Serotonin and dopamine are associated with multiple psychiatric disorders. How they interact during development to affect subsequent behavior remains unknown. Knockout of the serotonin transporter or postnatal blockade with selective serotonin reuptake inhibitors (SSRIs) leads to novelty-induced exploration deficits in adulthood, potentially involving the dopamine system. Here, we show in the mouse that raphe nucleus serotonin neurons activate ventral tegmental area dopamine neurons via glutamate co-transmission and that this co-transmission is reduced in animals exposed postnatally to SSRIs. Blocking serotonin neuron glutamate co-transmission mimics this SSRI-induced hypolocomotion, while optogenetic activation of dopamine neurons reverses this hypolocomotor phenotype. Our data demonstrate that serotonin neurons modulate dopamine neuron activity via glutamate co-transmission and that this pathway is developmentally malleable, with high serotonin levels during early life reducing co-transmission, revealing the basis for the reduced novelty-induced exploration in adulthood due to postnatal SSRI exposure.
科研通智能强力驱动
Strongly Powered by AbleSci AI