微泡
外体
肿瘤微环境
转移
生物
细胞信号
细胞生物学
肿瘤进展
细胞
信号转导
细胞内
癌症研究
肿瘤细胞
小RNA
癌症
基因
生物化学
遗传学
作者
Yujuan Huang,Masamitsu Kanada,Jiaxiang Ye,Yayan Deng,Qian He,Zhengyang Lei,Yong Chen,Yongqiang Li,Peiwu Qin,Jinyan Zhang,Jiazhang Wei
出处
期刊:Cancer Letters
[Elsevier]
日期:2022-09-01
卷期号:543: 215796-215796
被引量:39
标识
DOI:10.1016/j.canlet.2022.215796
摘要
Extracellular vesicles (EVs) are membrane-enveloped nanoscale particles that carry various bioactive signaling molecules secreted by cells. Their biological roles depend on the original cell type from which they are derived and their inclusions. Exosomes, a class of EVs, are released by almost all eukaryotic cell types, including tumor cells. Tumor cell-derived exosomes mediate signal transduction between tumor cells and surrounding non-tumor cells. This intercellular communication actively contributes to the remodeling of the tumor microenvironment (TME) to enable tumor growth, invasion, and metastasis. This review summarizes the latest progress in the exploration of exosome-mediated cell-cell communication implicated in TME remodeling and underlying mechanisms. We focus on the role of cell-cell interactions mediated by tumor cell-derived exosomes in promoting invasion and metastasis, and their potential as a therapeutic intervention target against distant metastasis. We also discuss the clinical translational significance of tumor-derived exosomes for early diagnosis, efficacy and progression evaluations.
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