重编程
机制(生物学)
肝细胞癌
生物
小RNA
癌症
肝癌
代谢途径
癌症研究
脂质代谢
细胞生物学
生物信息学
作者
Wenwei Liao,Jinpeng Du,Zhen Wang,Qingbo Feng,Mingheng Liao,Huixian Liu,Kefei Yuan,Yong Zeng
摘要
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Metabolic reprogramming is considered to be an important hallmark of cancer. Emerging studies have demonstrated that noncoding RNAs (ncRNAs) are closely associated with metabolic reprogramming of HCC. NcRNAs can directly regulate the expressions or functions of metabolic enzymes or indirectly regulate the metabolism of HCC cells through some vital signaling pathways. Until now, the mechanisms of HCC development and progression remain largely unclear, and understanding the regulatory mechanism of ncRNAs on metabolic reprogramming of HCC may provide an important basis for breakthrough progress in the treatment of HCC. In this review, we summarize the ncRNAs involved in regulating metabolic reprogramming of HCC. Specifically, the regulatory roles of ncRNAs in glucose, lipid and amino acid metabolism are elaborated. In addition, we discuss the molecular mechanism of ncRNAs in regulation of metabolic reprogramming and possible therapeutic strategies that target the metabolism of cancer cells by modulating the expressions of specific ncRNAs. This article is protected by copyright. All rights reserved.
科研通智能强力驱动
Strongly Powered by AbleSci AI