奥比努图库单抗
医学
膜性肾病
美罗华
肾病
免疫学
内科学
胃肠病学
抗体
肾小球肾炎
内分泌学
肾
糖尿病
作者
Noemi E Ginthör,Katharina Artinger,Marion J. Pollheimer,Martin H Stradner,Kathrin Eller
出处
期刊:Ndt Plus
[Oxford University Press]
日期:2021-12-08
卷期号:15 (3): 564-566
被引量:3
摘要
Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab.
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