百日咳博德特菌
佩克汀
百日咳毒素
微生物学
毒力
百日咳
生物
背景(考古学)
接种疫苗
丝状血凝素粘附素
病毒学
免疫
伞
抗原
免疫学
细菌
基因
遗传学
古生物学
受体
G蛋白
作者
Maciej Polak,Anna Lutyńska
出处
期刊:Postȩpy higieny i medycyny doświadczalnej
[Index Copernicus International]
日期:2017-05-09
卷期号:71 (1)
被引量:1
标识
DOI:10.5604/01.3001.0010.3821
摘要
Bordetella pertussis strains, which have lost the ability to produce antigens, such as pertactin - Prn, pertussis toxin - Ptx, filamentous haemagglutinin - FHA, fimbriae type 2 and 3 - Fim 2 and 3, tracheal colonization factor - TcfA, have recently been isolated in countries with a high vaccination coverage. The emergence of such isolates might have resulted from B. pertussis natural evolution course or adaptive mechanisms, allowing increased circulation of the pathogen in vaccinated populations. So far, the majority of described mutants were deficient in the Prn production. Prn deficient isolates were found in countries which use acellular pertussis vaccines (aP) in routine immunization programmes. The increase of frequency of Prn¯ strains isolation was correlated with the period of routine vaccination with aP vaccines. In most countries, the spread of these isolates has resulted from independent mutations rather than from the expansion of a single clone. Prn¯ isolates were collected from patients showing typical clinical symptoms of pertussis found for Prn+ strains. Results of in vitro and in vivo studies have shown that Prn¯, Ptx¯ and FHA¯ isolates retain cytotoxic properties, and besides Ptx¯ isolates, were lethal in intranasally infected mice. Further explanation of the impact of antigen deficiencies on virulence and transmission of B. pertussis in the context of the continuous increase of pertussis incidence is necessary to develop a new, optimized strategy of pertussis prevention.
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