微泡
串扰
细胞生物学
生物
细胞外
生物发生
激素
代谢途径
细胞外小泡
生物信息学
内分泌学
内科学
生物化学
新陈代谢
医学
小RNA
基因
物理
光学
作者
Sheng Hu,Yong Hu,Wei Yan
标识
DOI:10.1016/j.tem.2023.06.002
摘要
Abstract
The body partially maintains metabolic homeostasis through interorgan communication between metabolic organs under physiological conditions. This crosstalk is known to be mediated by hormones or metabolites, and has recently been expanding to include extracellular vesicles (EVs). EVs participate in interorgan communication under physiological and pathological conditions by encapsulating various bioactive cargoes, including proteins, metabolites, and nucleic acids. In this review we summarize the latest findings about the metabolic regulation of EV biogenesis, secretion, and components, and highlight the biological role of EV cargoes in interorgan communication in cancer, obesity, diabetes, and cardiovascular disease. We also discuss the potential application of EVs as diagnostic markers, and corresponding therapeutic strategies by EV engineering for both early detection and treatment of metabolic disorders.
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