间充质干细胞
间质细胞
细胞凋亡
炎症
细胞生物学
细胞外小泡
癌症研究
微泡
纤维化
医学
程序性细胞死亡
免疫学
生物
病理
小RNA
生物化学
基因
作者
Dilara C. Ozkocak,Ivan K. H. Poon
标识
DOI:10.1016/j.ymthe.2024.01.011
摘要
Mesenchymal stromal cells (MSCs) have garnered widespread attention for their potential use as a therapeutic to treat a vast range of inflammatory diseases such as graft-versus-host disease, type 1 diabetes, multiple sclerosis, and Crohn's disease.1 Current consensus has postulated that the mechanism underpinning MSCs' therapeutic action is via the secretion of cytokines, chemokines, and subcellular particles such as extracellular vesicles (EVs) from MSCs.2 Notably, since the discovery that infused MSCs do not engraft and can undergo apoptosis to exert immunoregulation,3,4 the importance of MSC cell death and factors that are released during the progression of apoptosis is of particular interest to the field.
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