生物膜
清创术(牙科)
医学
糖尿病足
菠萝蛋白酶
外科
金黄色葡萄球菌
细菌
糖尿病
生物
酶
生物化学
遗传学
蛋白酶
内分泌学
作者
Robert Snyder,Adam J. Singer,Cyaandi Dove,Stephen Heisler,Howard Petusevsky,Garth A. James,Elinor deLancey Pulcini,Aya Ben Yaakov,Lior Rosenberg,Edward G. Grant,Yaron Shoham
出处
期刊:Wounds-a Compendium of Clinical Research and Practice
[HMP Communications, LLC]
日期:2023-01-01
卷期号:35 (12): e414-e419
被引量:3
摘要
Background. Most chronic wounds contain biofilm, and debridement remains the centerpiece of treatment. Enzymatic debridement is an effective tool in removing nonviable tissue, however, there is little evidence supporting its effect on planktonic and biofilm bacteria. Objective. This study evaluated the effects of a novel BBD agent on removal of nonviable tissue, biofilm, and microbial loads in patients with chronic ulcers. Materials and Methods. Twelve patients with DFU or VLU were treated with up to 8 once-daily applications of BBD and then followed for an additional 2 weeks. Punch biopsy specimens were collected and analyzed for biofilm, and fluorescence imaging was used to measure bacterial load. Results. Ten patients completed treatment, and 7 achieved complete debridement within a median of 2 applications (range, 2–8). By the end of the 2-week follow-up period, the mean ± SD reduction in wound area was 35% ± 38. In all 6 patients who were positive for biofilm at baseline, the biofilm was reduced to single individual or no detected microorganisms by the end of treatment. Red fluorescence for Staphylococcus aureus decreased from a mean of 1.09 cm² ± 0.58 before treatment to 0.39 cm² ± 0.25 after treatment. BBD was safe and well tolerated. Conclusion. Preliminary data suggest that BBD is safe and that it can be used to effectively debride DFU and VLU, reduce biofilm and planktonic bacterial load, and promote reduction in wound size.
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