The role of hyaluronic acid in the design and functionalization of nanoparticles for the treatment of colorectal cancer

CD44细胞 透明质酸 结直肠癌 癌症 转移 药品 癌症研究 医学 纳米技术 化学 药理学 细胞 内科学 材料科学 生物化学 解剖
作者
Mariana Carlomagno de Paula,Suzana Gonçalves Carvalho,Amanda Letícia Polli Silvestre,Aline Martins dos Santos,Andréía Bagliotti Meneguin,Marlus Chorilli
出处
期刊:Carbohydrate Polymers [Elsevier BV]
卷期号:320: 121257-121257 被引量:25
标识
DOI:10.1016/j.carbpol.2023.121257
摘要

Despite advances in new approaches for colorectal cancer (CRC) therapy, intravenous chemotherapy remains one of the main treatment options; however, it has limitations associated with off-target toxicity, tumor cell resistance due to molecular complexity and CRC heterogeneity, which lead to tumor recurrence and metastasis. In oncology, nanoparticle-based strategies have been designed to avoid systemic toxicity and increase drug accumulation at tumor sites. Hyaluronic acid (HA) has obtained significant attention thanks to its ability to target nanoparticles (NPs) to CRC cells through binding to cluster-determinant-44 (CD44) and hyaluronan-mediated motility (RHAMM) receptors, along with its efficient biological properties of mucoadhesion. This review proposes to discuss the state of the art in HA-based nanoparticulate systems intended for localized treatment of CRC, highlighting the importance of the mucoadhesion and active targeting provided by this polymer. In addition, an overview of CRC will be provided, emphasizing the importance of CD44 and RHAMM receptors in this type of cancer and the current challenges related to this disease, and important concepts about the physicochemical and biological properties of HA will also be addressed. Finally, this review aims to contribute to the advancement of accuracy treatment of CRC by the design of new platforms based on by HA.
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