化学
四级碳
催化作用
还原消去
镍
碳纤维
组合化学
第四纪
中心(范畴论)
药物化学
有机化学
对映选择合成
结晶学
古生物学
材料科学
复合数
复合材料
生物
作者
Kai Chen,Qian Liu,Jinyan Wan,Chuan Zhu,Chao Feng
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-08-08
卷期号:25 (32): 5995-6000
被引量:4
标识
DOI:10.1021/acs.orglett.3c02102
摘要
A Ni-catalyzed reductive dicarbofunctionalization of α-CF3 styrenes with benzyl bromides has been accomplished. This transformation obviates the commonly facile β-F elimination effectively and enables the creation of CF3-substituted all-carbon quaternary centers of pharmaceutical interests. Preliminary mechanistic studies suggest a pathway consisting of benzyl radical addition and subsequent nickel-mediated benzylation of the resulting α-CF3-embedded tertiary C radical.
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