氨甲环酸
医学
血液透析
纤溶
丸(消化)
透析
麻醉
外科
纤溶酶原激活剂
内科学
失血
作者
Ryogo Yoshii,Yuya Takahashi,Teiji Sawa,Fumimasa Amaya,Satoshi Ogawa
出处
期刊:A&A practice
[Ovid Technologies (Wolters Kluwer)]
日期:2023-05-01
卷期号:17 (5): e01676-e01676
被引量:2
标识
DOI:10.1213/xaa.0000000000001676
摘要
A 61-year-old woman with chronic renal dysfunction was scheduled to undergo aortic valve replacement. After a bolus of 1 g tranexamic acid (TXA), the TPA (tissue-plasminogen activator)-test result with the ClotPro system demonstrated extensive inhibition of fibrinolysis. Plasma TXA level decreased from 71 to 25 μg/dL at 6 hours postoperatively; however, no further decrease was observed. Although TXA levels dropped to 6.9 μg/dL after hemodialysis on postoperative day (PoD) 1, fibrinolytic shutdown on the TPA-test remained unchanged until PoD 2. In dialysis patients, low-dose TXA <1 g may be considered for reducing seizure and thromboembolic complications after cardiac surgery.
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