阳离子聚合
两亲性
四苯乙烯
单体
荧光
化学
抗菌剂
骨料(复合)
光化学
有机化学
材料科学
聚合物
纳米技术
聚集诱导发射
共聚物
物理
量子力学
作者
Chengcheng Zhou,Zeyu Ding,Weijiang Guan,Ben Zhong Tang
出处
期刊:Aggregate
[Wiley]
日期:2023-06-06
卷期号:4 (5)
摘要
Abstract Cationic amphiphile aggregates exhibit superior antibacterial activity than monomers. However, the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor aggregate and monomer in antimicrobial process. Herein, three bola‐type cationic amphiphiles with aggregation‐induced emission property have been developed to show distinguishable fluorescence in their monomer and aggregate. The hydrophilicity of monomer and the stability of aggregate are finely tuned by tailoring the linkers between two quaternary ammonium end groups and tetraphenylethylene skeleton. The sensitive fluorescence switching of monomer and aggregate achieves the quantitative monitoring of dynamic interaction of three amphiphiles with bacteria. The aggregates with cationic charges first attach to bacterial surface, and the monomers subsequently dissociate from aggregates to penetrate bacterial membrane. Further, our results reveal the vital role of stability of aggregates during antimicrobial process, shedding light on the rational design of high‐efficient antimicrobials.
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