阿魏酸
自愈水凝胶
化学
DPPH
阿布茨
抗氧化剂
漆酶
肿胀 的
核化学
有机化学
生物化学
酶
化学工程
工程类
作者
Virginie Dulong,Marie-Carole Kouassi,Béatrice Labat,Didier Le Cerf,Luc Picton
标识
DOI:10.1016/j.foodchem.2018.04.046
摘要
Antioxidant and cytocompatible chemically modified polysaccharides and their hydrogels were obtained by a biomimetic approach. For this purpose, carboxymethylpullulan grafted with ferulic acid (CMP-FA) was firstly synthesized with different substitution degrees (DSFA). Their hydrogels were secondly obtained by enzymatic cross-linking with laccase. Hydrogel swelling has been found dependent on both DSFA and media ionic strength. The CMP-FA antioxidant properties were evaluated by the DPPH method and ABTS assays. The DPPH radical scavenging effect was high for CMP-FA solutions (80% after 30 min) and lower for the corresponding hydrogels (70% after 7 h). The antibacterial properties of ferulic acid and CMP-FA derivatives were tested against Staphylococcus aureus but the minimal inhibitory concentration of CMP-FA was not reached in the range of concentrations studied. Finally the CMP-FA derivatives showed no cytotoxicity towards mouse fibroblast cells.
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