化学
分子内力
区域选择性
催化作用
四级碳
协议(科学)
组合化学
有机化学
对映选择合成
医学
替代医学
病理
作者
Lin‐Bao Zhang,Zi‐Chen Wang,Sheng‐Zheng Sun,Shao‐Fei Ni,Li‐Rong Wen,Ming Li
标识
DOI:10.1002/cjoc.202000534
摘要
Main observation and conclusion Through the intramolecular cyclization of N ‐methoxybenzamides, a simple and efficient method for constructing valuable isoindolinones under metal‐free conditions was developed. The reaction was featured by employing low‐cost catalyst, simple operation, 100% atomic economy and excellent regioselectivity. Moreover, a detailed computational study on the reaction system has been performed to clarify the mechanism. This protocol tolerated a variety of functional groups and provided a metal‐free protocol for the synthesis of chromane‐ or tetrahydroquinoline‐fused isoindolinones in good yields.
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