级联
纳米技术
化学
可重用性
金属有机骨架
材料科学
组合化学
生物传感器
级联反应
酶
生物相容性材料
纳米医学
生化工程
有机化学
计算机科学
催化作用
纳米颗粒
色谱法
工程类
吸附
生物医学工程
程序设计语言
软件
作者
Jieying Liang,Kang Liang
标识
DOI:10.1002/tcr.202000067
摘要
Abstract Multi‐enzyme cascade reactions are indispensable in biotechnology and many industrial (bio)chemical processes. However, most natural enzymes have poor stability and reusability, and tend to inactivate in toxic media or high temperature, which significantly limit their broader applications. Metal‐organic frameworks (MOFs) are promising candidates for enzymes immobilization to produce nanocomposite structures that not only could shield the enzymes from harsh environments, but also facilitate selective diffusion of substrates and intermediates to the reactive site via their tailorable and ordered pore network. Multi‐enzyme cascade reactions in MOFs have recently attracted considerable attention. This Personal Account discusses the different strategies for multi‐enzyme‐MOF interfaces and their cutting‐edge applications from biosensing and catalytic nanomedicine to artificial/hybrid cells. At last, we provide a critical evaluation and future prospects to outline future research directions.
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