Research advances in pathophysiology, diagnosis and therapy of trauma-induced coagulopathy

Objective Trauma-induced coagulopathy(TIC)is an acute coagulopathy in which coagulation, fibrinolysis, and anticoagulant pathways are activated after trauma due to massive hemorrhage and tissue damage. TIC is caused by hypothermia, acidosis, blood dilution, hyperfusion, tissue injury, etc. To diagnose TIC, we mainly rely on traditional coagulation function analysis and thrombelastogram (TEG). At present, the key to treat TIC is quick hemostasis. The basic treatment procedure includes transfusion of packed red blood cells and fresh frozen plasma by appropriate proportion, and timely infusion of platelets and coagulant material so as to stabilize blood pressure and reconstruct the blood coagulation mechanism. In this paper, we reviewed recent advances in the pathophysiological and treatment of TIC in order to provide references for further research in related fields. Key words: Blood coagulation disorders; Wounds and injuries; Pathology; Physiology; Diagnosis and treatment