神经保护
氧化应激
睡眠剥夺
白藜芦醇
神经炎症
药理学
谷胱甘肽过氧化物酶
内分泌学
内科学
化学
医学
神经科学
炎症
生物
超氧化物歧化酶
认知
作者
Yujuan Li,Xie Zheng,Xiaoxiao Luo,Xuan Wang,Yue Wang,Mingke Guo,Zhiqiang Zhou,Rao Sun,Hua Duan,Ailin Luo,Shiyong Li
标识
DOI:10.1002/mnfr.202200735
摘要
Sleep deprivation (SD) negatively affects all aspects of health, with one serious consequence being impaired cognition. Farnesol (FOL) is a sesquiterpene synthesized by plants and mammals that has antioxidant, anti-inflammatory, and neuroprotective properties. This study investigates the mechanism underlying the neuroprotective effect of FOL on SD-induced cognitive impairment.Administration of FOL dramatically ameliorates chronic sleep deprivation (CSD)-induced cognitive impairment. In addition, FOL notably attenuates oxidative stress damage, pro-inflammatory cytokines activation, and microglial activation in the hippocampi of the CSD-exposed mice. Further examination indicates that administration of FOL after the CSD significantly increases the protein expressions of silent information regulator factor 2-related enzyme 1 (Sirt1), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and glutathione peroxidase 4 (Gpx4) in the hippocampi. Sirt1 agonist resveratrol (RES) has a similar neuroprotective effect, indicating that FOL could exert neuroprotective effects through the activation of the Sirt1/Nrf2 signaling pathway.The results reveal that FOL could protect against CSD-induced cognitive impairment by activating the Sirt1/Nrf2 signaling pathway.
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