脂质体
神经炎症
血脑屏障
药理学
体内
神经保护
药物输送
药品
氧化应激
化学
医学
中枢神经系统
炎症
免疫学
生物
生物化学
内科学
有机化学
生物技术
作者
Xinyue Zhang,Ning‐Ning Shi,Muhan Chen,Mo Liu,Rui-Jun Ju,Yang Liu,Liang Kong,Yang Yu,Xuetao Li
标识
DOI:10.1080/1061186x.2023.2216405
摘要
The blood-brain barrier (BBB) is a barrier that maintains brain homeostasis, but it is also one of the major problems that must be overcome in the development of Alzheimer's disease (AD) drugs. To solve this problem, Salidroside (Sal) and Icariin (Ica), drugs with neuroprotective effects were loaded into liposomes, and the targeting molecule Angiopep-2 was modified on the surface of liposomes (Ang-Sal/Ica-Lip), so that the constructed nano-drug delivery system could effectively cross the BBB and exert anti-AD effects. The prepared liposomes exhibited ideal physicochemical properties. In vitro and in vivo targeting studies showed that Ang-Sal/Ica liposome could cross the BBB to increase drug accumulation in the brain, and increase the uptake of N2a cells and bEnd.3 cells. The pharmacodynamic analysis in vivo showed that Ang-Sal/Ica liposome could reverse neuronal and synaptic damage, inhibit neuroinflammation and oxidative stress and improve learning and cognitive function. Therefore, Ang-Sal/Ica liposome may be a promising therapeutic strategy for mitigating AD-related symptoms.
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