Association of Endocrine-Disrupting Chemicals with All-Cause and Cause-Specific Mortality in the U.S.: A Prospective Cohort Study

环境卫生 医学 邻苯二甲酸盐 全国健康与营养检查调查 比例危险模型 队列研究 队列 死亡率 全国死亡指数 危险系数 内分泌系统 前瞻性队列研究 人口学 人口 内科学 化学 置信区间 有机化学 社会学 激素
作者
Yun Fan,Chengzhe Tao,Zhi Li,Yuna Huang,Wenkai Yan,Shuangshuang Zhao,Beibei Gao,Qiaoqiao Xu,Yufeng Qin,Xinru Wang,Zhihang Peng,Adrian Covaci,You Li,Yankai Xia,Chuncheng Lu
出处
期刊:Environmental Science & Technology [American Chemical Society]
卷期号:57 (7): 2877-2886 被引量:28
标识
DOI:10.1021/acs.est.2c07611
摘要

Wide exposure to endocrine-disrupting chemicals (EDCs) poses a great risk on human health. However, few large-scale cohort studies have comprehensively estimated the association between EDCs exposure and mortality risk. This study aimed to investigate the association of urinary EDCs exposure with mortality risk and quantify attributable mortality and economic loss. Multivariable Cox proportional hazards regression models were performed to investigate the association of 38 representative EDCs exposure with mortality risk in the National Health and Nutrition Examination Survey (NHANES). During a median follow-up of 7.7 years, 47,279 individuals were enrolled. All-cause mortality was positively associated with 1-hydroxynaphthalene, 2-hydroxynaphthalene, cadmium, antimony, cobalt, and monobenzyl phthalate. Cancer mortality was positively associated with cadmium. Cardiovascular disease (CVD) mortality was positively associated with 1-hydroxynaphthalene, 2-hydroxynaphthalene, and 2-hydroxyfluorene. Nonlinear U-shaped relationships were found between all-cause mortality and cadmium and cobalt, which was also identified between 2-hydroxyfluorene and CVD mortality. J-shaped association of cadmium exposure with cancer mortality was also determined. EDCs exposure may cause 56.52% of total deaths (1,528,500 deaths) and around 1,897 billion USD in economic costs. Exposure to certain phthalates, polycyclic aromatic hydrocarbons, phytoestrogens, or toxic metals, even at substantially low levels, is significantly associated with mortality and induces high economic costs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
CC完成签到,获得积分10
刚刚
wwuu发布了新的文献求助10
1秒前
shenyanlei发布了新的文献求助10
1秒前
一汁蟹发布了新的文献求助20
2秒前
大个应助绿麦盲区采纳,获得10
2秒前
雨齐完成签到,获得积分10
2秒前
茶艺如何发布了新的文献求助10
2秒前
2秒前
kk完成签到,获得积分10
3秒前
3秒前
123发布了新的文献求助10
3秒前
yyyy完成签到,获得积分10
4秒前
好好学习天天向上完成签到,获得积分10
4秒前
欣慰友梅发布了新的文献求助10
4秒前
4秒前
5秒前
Akim应助易伊澤采纳,获得10
5秒前
格局太小完成签到,获得积分10
5秒前
5秒前
尔云完成签到,获得积分10
6秒前
传奇3应助GGZ采纳,获得10
6秒前
我瞎蒙发布了新的文献求助10
6秒前
llllllll完成签到,获得积分10
7秒前
香蕉觅云应助shenyanlei采纳,获得10
7秒前
kdkfjaljk完成签到 ,获得积分10
7秒前
7秒前
CipherSage应助芒果采纳,获得10
7秒前
7秒前
8秒前
nini完成签到,获得积分10
8秒前
8秒前
8秒前
FloppyWow发布了新的文献求助10
9秒前
9秒前
9秒前
白白发布了新的文献求助10
10秒前
隐形曼青应助小猴采纳,获得10
10秒前
灵巧荆发布了新的文献求助10
10秒前
11秒前
kdkfjaljk关注了科研通微信公众号
12秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Social media impact on athlete mental health: #RealityCheck 1020
Ensartinib (Ensacove) for Non-Small Cell Lung Cancer 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
Bacterial collagenases and their clinical applications 800
El viaje de una vida: Memorias de María Lecea 800
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3527723
求助须知:如何正确求助?哪些是违规求助? 3107826
关于积分的说明 9286663
捐赠科研通 2805577
什么是DOI,文献DOI怎么找? 1539998
邀请新用户注册赠送积分活动 716878
科研通“疑难数据库(出版商)”最低求助积分说明 709762