Usefulness of Longitudinal Strain to Assess Cancer Therapy-Related Cardiac Dysfunction and Immune Checkpoint Inhibitor-Induced Myocarditis

医学 不利影响 心肌炎 癌症 中止 内科学 肿瘤科 重症监护医学
作者
Yudai Tamura,Yuichi Tamura
出处
期刊:Pharmaceuticals [MDPI AG]
卷期号:16 (9): 1297-1297 被引量:4
标识
DOI:10.3390/ph16091297
摘要

Longitudinal strain (LS) measured by echocardiography has been reported to be useful not only for the diagnosis and risk stratification of various cardiac diseases, but also in cardio-oncology. Most previous studies have been conducted on patients undergoing treatment with anthracyclines and human epidermal growth factor receptor 2-targeted therapies. Existing guidelines recommend that global LS (GLS) should be measured before and after the administration of cancer drugs. This recommendation is based on many reports showing that a decline in GLS is indicative of early or mild cancer therapy-related cardiac dysfunction. The main purpose of this article is to provide insight into the importance of LS in patients undergoing cancer treatment and highlight the role of LS evaluation in patients undergoing immune checkpoint inhibitor (ICI) treatment, which is being used with increasing frequency. Among cancer drug therapies, immune checkpoint inhibitors (ICIs) have an important place in cancer treatment and are used for the treatment of many types of cancer. Although the efficacy of ICIs in cancer treatment has been reported, immune-related adverse events (irAEs) have also been reported. Among these irAEs, cardiovascular complications, although rare, are recognized as important adverse events that may result in ICI treatment discontinuation. Myocarditis is one severe adverse event associated with ICIs, and it is important to standardize diagnostic and therapeutic approaches to it. Several studies have reported a relationship between LS and cardiac complications associated with ICIs which may contribute to the early diagnosis of ICI-induced cardiac complications.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
heew发布了新的文献求助10
刚刚
刚刚
dmm发布了新的文献求助10
刚刚
美好依瑶完成签到,获得积分10
1秒前
5秒前
zyr完成签到,获得积分10
5秒前
美好依瑶发布了新的文献求助10
5秒前
dmm完成签到,获得积分10
7秒前
义气绿柳发布了新的文献求助10
8秒前
在水一方应助shoplog采纳,获得10
10秒前
拼搏的宛丝完成签到,获得积分10
10秒前
livrese完成签到,获得积分10
10秒前
CipherSage应助烊烊采纳,获得10
10秒前
11秒前
heew完成签到,获得积分10
11秒前
NexusExplorer应助付清采纳,获得10
12秒前
同尘完成签到 ,获得积分10
12秒前
13秒前
大模型应助Fearless采纳,获得10
14秒前
科研通AI5应助meena采纳,获得30
14秒前
我是老大应助深情素阴采纳,获得10
16秒前
热心的土豆窝窝头完成签到 ,获得积分10
16秒前
今我来思发布了新的文献求助10
17秒前
18秒前
cl发布了新的文献求助10
18秒前
杨沉淀完成签到 ,获得积分10
19秒前
糊涂的小伙完成签到,获得积分10
20秒前
22秒前
22秒前
22秒前
22秒前
129600发布了新的文献求助10
23秒前
欧皇完成签到,获得积分10
24秒前
图图完成签到,获得积分20
24秒前
梁小鑫发布了新的文献求助10
26秒前
26秒前
shoplog发布了新的文献求助10
26秒前
小芃发布了新的文献求助10
26秒前
shaco发布了新的文献求助10
27秒前
ftx发布了新的文献求助10
28秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
1.3μm GaAs基InAs量子点材料生长及器件应用 1000
Ensartinib (Ensacove) for Non-Small Cell Lung Cancer 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
El viaje de una vida: Memorias de María Lecea 800
Luis Lacasa - Sobre esto y aquello 700
Novel synthetic routes for multiple bond formation between Si, Ge, and Sn and the d- and p-block elements 700
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3525973
求助须知:如何正确求助?哪些是违规求助? 3106420
关于积分的说明 9280254
捐赠科研通 2804049
什么是DOI,文献DOI怎么找? 1539151
邀请新用户注册赠送积分活动 716511
科研通“疑难数据库(出版商)”最低求助积分说明 709462