Identification and multicentric validation of soluble CDCP1 as a robust serological biomarker for risk stratification of NASH in obese Chinese

生物标志物 医学 脂肪性肝炎 内科学 接收机工作特性 置信区间 肝活检 胃肠病学 病理 活检 脂肪肝 生物 疾病 生物化学
作者
Xi Jia,Erfei Song,Yan Liu,Jiarui Chen,Pei Wan,Yue Hu,Dewei Ye,Subrata Chakrabarti,Hema Mahajan,Jacob George,Sen Yan,Yong-tao Yu,Guanghui Zhang,Yong Wang,Wah Yang,Lihong Wu,Shuang Hua,Chi‐Ho Lee,Huixin Li,Xue Jiang,Karen S.L. Lam,Cunchuan Wang,Aimin Xu
出处
期刊:Cell reports medicine [Elsevier BV]
卷期号:4 (11): 101257-101257 被引量:4
标识
DOI:10.1016/j.xcrm.2023.101257
摘要

Summary

The definitive diagnosis of non-alcoholic steatohepatitis (NASH) currently relies on invasive and labor-intensive liver biopsy. Here, we identified soluble CUB domain-containing protein 1 (sCDCP1) as a top-ranked non-invasive biomarker for NASH using Olink-based proteomics in 238 obese individuals with liver biopsies. Both the circulating concentration and hepatic mRNA abundance of sCDCP1 were significantly elevated in patients with NASH and correlated closely with each histological feature of NASH. In the pooled multicenter validation cohort, sCDCP1 as a standalone biomarker achieved an area under the receiver operating characteristic (AUROC) of 0.838 (95% confidence interval [CI] 0.789–0.887) for diagnosing NASH, which is better than those achieved with cytokeratin-18 and other non-invasive tests. Furthermore, the C-DAG model established by the combination of sCDCP1 with diabetes, aspartate aminotransferase (AST), and gender accurately rules in and rules out both NASH and fibrotic NASH (gray zones <20%). Thus, sCDCP1-based non-invasive tests can be potentially implemented for screening and early diagnosis of NASH and for ruling out low-risk individuals to avoid unnecessary liver biopsies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
仁和完成签到 ,获得积分10
刚刚
1秒前
Tina完成签到,获得积分10
1秒前
王哈哈完成签到,获得积分20
1秒前
3秒前
SciGPT应助科研通管家采纳,获得30
3秒前
quhayley应助科研通管家采纳,获得10
3秒前
香蕉觅云应助科研通管家采纳,获得10
3秒前
情怀应助科研通管家采纳,获得10
3秒前
丘比特应助科研通管家采纳,获得10
4秒前
赘婿应助科研通管家采纳,获得10
4秒前
4秒前
4秒前
SHAO应助科研通管家采纳,获得10
4秒前
Jasper应助科研通管家采纳,获得10
4秒前
March应助科研通管家采纳,获得10
4秒前
赘婿应助科研通管家采纳,获得10
4秒前
fd163c应助科研通管家采纳,获得10
4秒前
SYLH应助科研通管家采纳,获得20
4秒前
脑洞疼应助科研通管家采纳,获得10
4秒前
慕青应助科研通管家采纳,获得10
5秒前
无花果应助科研通管家采纳,获得10
5秒前
quhayley应助科研通管家采纳,获得10
5秒前
bkagyin应助科研通管家采纳,获得30
5秒前
搜集达人应助科研通管家采纳,获得10
5秒前
5秒前
传奇3应助科研通管家采纳,获得10
5秒前
Lucas应助科研通管家采纳,获得50
5秒前
5秒前
5秒前
6秒前
陈曦发布了新的文献求助10
6秒前
6秒前
6秒前
JamesPei应助科研通管家采纳,获得10
6秒前
6秒前
SYLH应助科研通管家采纳,获得20
6秒前
Atan完成签到,获得积分10
7秒前
Kevin发布了新的文献求助10
7秒前
7秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021