二氟卡宾
化学
芳基
苯酚
甲酰化
乙醚
表面改性
酚类
组合化学
有机化学
烷基
催化作用
物理化学
作者
Cong‐Cong Feng,Songlin Zhang
摘要
A convenient method to prepare aryl formates is reported herein that exploits difluorocarbene to serve as a CO surrogate. This reaction is proposed to occur through a sequential O-difluoromethylation of phenol, followed by α-C-F bond functionalization of the resulting aryl difluoromethyl ether intermediate by phenol or moisture through fluorosemiacetal or orthoformate intermediates. Late-stage modification of biologically and materially active compounds is demonstrated.
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