Integrated Clinical Genotype-phenotype Characteristics of STAT3-mutated Myeloid Neoplasms

STAT3 is a key transcription factor that mediates cancer progression through phosphorylation or gain-of-function mutations. STAT3 activation in myeloid neoplasms (MNs) is primarily mediated through phosphorylation. STAT3 mutation has only rarely been reported in MNs.