Meta-analysis of sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with initial biopsy-proven node-positive breast cancer

医学 乳腺癌 活检 前哨淋巴结 腋窝淋巴结清扫术 淋巴结 哨兵节点 新辅助治疗 腋窝 放射科 外科 癌症 内科学
作者
Syer Ree Tee,Liam Devane,Denis Evoy,Jane Rothwell,James Geraghty,Ruth Prichard,Enda McDermott
出处
期刊:British Journal of Surgery [Oxford University Press]
卷期号:105 (12): 1541-1552 被引量:110
标识
DOI:10.1002/bjs.10986
摘要

Abstract Background Neoadjuvant chemotherapy for breast cancer has the potential to achieve a pathological complete response in up to 40 per cent of patients, converting disease that was initially node-positive to node-negative. This has raised the question of whether sentinel lymph node biopsy could be an alternative to axillary lymph node dissection in these patients. The aim was to undertake a systematic review and meta-analysis of the accuracy and reliability of sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with initial biopsy-proven node-positive breast cancer. Methods A literature search was conducted using PubMed, Ovid MEDLINE, Embase and Web of Science databases up to 30 April 2017. Inclusion criteria for studies were pathological confirmation of initial node-positive disease, and sentinel lymph node biopsy performed after neoadjuvant chemotherapy followed by axillary lymph node dissection. Results A total of 13 studies met the inclusion criteria and were included in the analysis (1921 patients in total). The pooled estimate of identification rate was 90 (95 per cent c.i. 87 to 93) per cent and the false-negative rate was 14 (11 to 17) per cent. In subgroup analysis, the false-negative rate with use of dual mapping was 11 (6 to 15) per cent, compared with 19 (11 to 27) per cent with single mapping. The false-negative rate was 20 (13 to 27) per cent when one node was removed, 12 (5 to 19) per cent with two nodes removed and 4 (0 to 9) per cent with removal of three or more nodes. Conclusion Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with biopsy-proven node-positive breast cancer is accurate and reliable, but requires careful patient selection and optimal surgical techniques.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
AiX-zzzzz发布了新的文献求助10
刚刚
量子星尘发布了新的文献求助10
刚刚
1秒前
明理凝阳发布了新的文献求助10
1秒前
2秒前
ttnnn完成签到,获得积分10
2秒前
2秒前
好名字发布了新的文献求助10
2秒前
颖儿发布了新的文献求助10
2秒前
rr发布了新的文献求助30
2秒前
3秒前
3秒前
黄纪毅完成签到,获得积分10
3秒前
niliuguang发布了新的文献求助10
3秒前
syangZ发布了新的文献求助10
3秒前
小清发布了新的文献求助30
3秒前
李爱国应助monets采纳,获得10
3秒前
852应助粗犷的凌兰采纳,获得10
4秒前
4秒前
4秒前
眼睛大雨筠应助xiaozeng采纳,获得40
4秒前
5秒前
雪白卿完成签到,获得积分10
5秒前
6秒前
结实的问寒完成签到,获得积分20
6秒前
6秒前
研友_LOoomL发布了新的文献求助10
7秒前
共享精神应助XHH1994采纳,获得10
7秒前
wzh1745发布了新的文献求助10
7秒前
三三关注了科研通微信公众号
7秒前
7秒前
sjx发布了新的文献求助10
8秒前
mirrovo发布了新的文献求助10
8秒前
8秒前
静仰星空发布了新的文献求助10
9秒前
Young完成签到,获得积分10
9秒前
想得开居士完成签到,获得积分10
9秒前
10秒前
zz完成签到,获得积分10
10秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970240
求助须知:如何正确求助?哪些是违规求助? 3514997
关于积分的说明 11176725
捐赠科研通 3250268
什么是DOI,文献DOI怎么找? 1795244
邀请新用户注册赠送积分活动 875725
科研通“疑难数据库(出版商)”最低求助积分说明 805004