纺神星
萧条(经济学)
认知
谷氨酸的
精神分裂症(面向对象编程)
心理学
重性抑郁障碍
神经科学
双相情感障碍
认知功能衰退
精神科
疾病
临床心理学
医学
谷氨酸受体
痴呆
内科学
宏观经济学
经济
受体
肾
作者
Patrycja Pańczyszyn-Trzewik,Ewelina Czechowska,Katarzyna Stachowicz,Magdalena Sowa-Kućma
标识
DOI:10.3390/ijms242015268
摘要
Depression is a serious neuropsychiatric disease affecting an increasing number of people worldwide. Cognitive deficits (including inattention, poor memory, and decision-making difficulties) are common in the clinical picture of depression. Cognitive impairment has been hypothesized to be one of the most important components of major depressive disorder (MDD; referred to as clinical depression), although typical cognitive symptoms are less frequent in people with depression than in people with schizophrenia or bipolar disorder (BD; sometimes referred to as manic-depressive disorder). The importance of α-Klotho in the aging process has been well-documented. Growing evidence points to the role of α-Klotho in regulating other biological functions, including responses to oxidative stress and the modulation of synaptic plasticity. It has been proven that a Klotho deficit may contribute to the development of various nervous system pathologies, such as behavioral disorders or neurodegeneration. Given the growing evidence of the role of α-Klotho in depression and cognitive impairment, it is assumed that this protein may be a molecular link between them. Here, we provide a research review of the role of α-Klotho in depression and cognitive impairment. Furthermore, we propose potential mechanisms (related to oxidative stress and glutamatergic transmission) that may be important in α-Klotho-mediated regulation of mental and cognitive function.
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