生物
毛螺菌科
免疫球蛋白A
益生元
微生物群
微生物学
表型
免疫系统
免疫
分泌性IgA
抗体
小肠
免疫学
细菌
免疫球蛋白G
遗传学
基因
厚壁菌
生物化学
16S核糖体RNA
作者
Shan Zhang,Yi Han,Whitman B. Schofield,Michael Nicosia,Paul Karell,Kevin P. Newhall,Julie Y. Zhou,Ryan Musich,Siyi Pan,Anna Valujskikh,Naseer Sangwan,Mohammed Dwidar,Qiuhe Lu,Thaddeus S. Stappenbeck
标识
DOI:10.1016/j.chom.2023.09.001
摘要
Immunoglobulin A (IgA) is an important factor in maintaining homeostasis at mucosal surfaces, yet luminal IgA levels vary widely. Total IgA levels are thought to be driven by individual immune responses to specific microbes. Here, we found that the prebiotic, pectin oligosaccharide (pec-oligo), induced high IgA levels in the small intestine in a T cell-dependent manner. Surprisingly, this IgA-high phenotype was retained after cessation of pec-oligo treatment, and microbiome transmission either horizontally or vertically was sufficient to retain high IgA levels in the absence of pec-oligo. Interestingly, the bacterial taxa enriched in the overall pec-oligo bacterial community differed from IgA-coated microbes in this same community. Rather, a group of ethanol-resistant microbes, highly enriched for Lachnospiraceae bacterium A2, drove the IgA-high phenotype. These findings support a model of intestinal adaptive immunity in which a limited number of microbes can promote durable changes in IgA directed to many symbionts.
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