三嗪
甲苯
噻吩
光催化
共价键
化学
光化学
组合化学
有机化学
催化作用
作者
Sizhe Li,Nikals Huber,Wei Huang,Wenxin Wei,Katharina Landfester,Calum T. J. Ferguson,Yan Zhao,Kai Zhang
标识
DOI:10.1002/ange.202400101
摘要
Investigations into the selective oxidation of inert sp3 C–H bonds using polymer photocatalysts under mild conditions have been limited. Additionally, the structure–activity relationship of photocatalysts often remains insufficiently explored. Here, a series of thiophene‐based covalent triazine frameworks (CTFs) are used for the efficient and selective oxidation of hydrocarbons to aldehydes or ketones under ambient aerobic conditions. Spectroscopic methods conducted in situ and density functional theory (DFT) calculations revealed that the sulfur atoms within the thiophene units play a pivotal role as oxidation sites due to the generation of photogenerated holes. The effect of photogenerated holes on photocatalytic toluene oxidation was investigated by varying the length of the spacer in a CTF donor–acceptor based photocatalyst. Furthermore, the manipulation of reactive oxygen species was employed to enhance selectivity by weakening the peroxidative capacity. As an illustrative example, this study successfully demonstrated the synthesis of a precursor of the neurological drug AMG‐579 using a photocatalytic protocol.
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