Evaluating the relationship between depression, suicidal thoughts and ulcerative colitis in patients with acne on isotretinoin: a case–control study

Our case–control study investigated the association between isotretinoin use and the incidence of depression, suicidal thoughts and ulcerative colitis among 14 365 patients with acne using the All of Us open-access database. The findings revealed no statistically significant correlation between isotretinoin use and these conditions, supporting the safety profile of isotretinoin in dermatological treatments.