生物相容性
二肽
自愈水凝胶
化学
自组装
组合化学
纳米技术
肽
材料科学
有机化学
生物化学
作者
Liangchun Li,Jingchi Li,Renlin Zheng,Rongqin Sun
标识
DOI:10.3389/fchem.2021.739791
摘要
Self-assembly peptide-based hydrogels are well known and popular in biomedical applications due to the fact that they are readily controllable and have biocompatibility properties. A dipeptide is the shortest self-assembling motif of peptides. Due to its small size and simple synthesis method, dipeptide can provide a simple and easy-to-use method to study the mechanism of peptides' self-assembly. This review describes the design and structures of self-assembly linear dipeptide hydrogels. The strategies for preparing the new generation of linear dipeptide hydrogels can be divided into three categories based on the modification site of dipeptide: 1) COOH-terminal and N-terminal modified dipeptide, 2) C-terminal modified dipeptide, and 3) uncapped dipeptide. With a deeper understanding of the relationship between the structures and properties of dipeptides, we believe that dipeptide hydrogels have great potential application in preparing minimal biocompatible materials.
科研通智能强力驱动
Strongly Powered by AbleSci AI