An adaptive platform trial for evaluating treatments in patients with life‐threatening hemorrhage from traumatic injuries: Planning and execution

TransfusionEarly View ADAPTIVE PLATFORM TRIAL DESIGN An adaptive platform trial for evaluating treatments in patients with life-threatening hemorrhage from traumatic injuries: Planning and execution Deborah J. del Junco, Corresponding Author Deborah J. del Junco deborah.j.deljunco.ctr@mail.mil Joint Trauma System, Defense Health Agency, San Antonio, Texas, USA Correspondence Deborah J. del Junco, Epidemiology & Biostatistics Section, Data Enterprise Branch Joint Trauma System, Defense Health Agency 3698 Chambers Pass, JBSA Fort Sam Houston, TX 78234-6315, USA. Email: deborah.j.deljunco.ctr@mail.milSearch for more papers by this authorMatthew D. Neal, Matthew D. Neal Department of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorStacy A. Shackelford, Stacy A. Shackelford orcid.org/0000-0003-3585-2150 Joint Trauma System, Defense Health Agency, San Antonio, Texas, USASearch for more papers by this authorPhilip C. Spinella, Philip C. Spinella orcid.org/0000-0003-1721-0541 Department of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorFrancis X. Guyette, Francis X. Guyette Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorJason L. Sperry, Jason L. Sperry Department of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorRoger J. Lewis, Roger J. Lewis Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA Statistics and Software, Berry Consultants, LLC, Austin, Texas, USASearch for more papers by this authorKabir Yadav, Kabir Yadav orcid.org/0000-0002-1092-9935 Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USASearch for more papers by this author Deborah J. del Junco, Corresponding Author Deborah J. del Junco deborah.j.deljunco.ctr@mail.mil Joint Trauma System, Defense Health Agency, San Antonio, Texas, USA Correspondence Deborah J. del Junco, Epidemiology & Biostatistics Section, Data Enterprise Branch Joint Trauma System, Defense Health Agency 3698 Chambers Pass, JBSA Fort Sam Houston, TX 78234-6315, USA. Email: deborah.j.deljunco.ctr@mail.milSearch for more papers by this authorMatthew D. Neal, Matthew D. Neal Department of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorStacy A. Shackelford, Stacy A. Shackelford orcid.org/0000-0003-3585-2150 Joint Trauma System, Defense Health Agency, San Antonio, Texas, USASearch for more papers by this authorPhilip C. Spinella, Philip C. Spinella orcid.org/0000-0003-1721-0541 Department of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorFrancis X. Guyette, Francis X. Guyette Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorJason L. Sperry, Jason L. Sperry Department of Surgery and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorRoger J. Lewis, Roger J. Lewis Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA Statistics and Software, Berry Consultants, LLC, Austin, Texas, USASearch for more papers by this authorKabir Yadav, Kabir Yadav orcid.org/0000-0002-1092-9935 Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USASearch for more papers by this author First published: 24 June 2022 https://doi.org/10.1111/trf.16982 The opinions and assertions expressed herein are those of the authors and do not necessarily reflect the official policy or position of the Uniformed Services University, the Defense Health Agency, or the Department of Defense. 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