Ganoderma lucidum spores (GLS) are the mature germ cells of Ganoderma lucidum. They have all the genetic substances and similar active components of Ganoderma lucidum. Similar to the fruiting body of Ganoderma lucidum, ganoderma spores powder has the effect of regulating immunity, antitumor, antioxidation, and protecting cells and so on. In recent decades, with the development of the technology of breaking the wall of Ganoderma lucidum spores and the technology of extracting and preparing, the researches and application of Ganoderma lucidum spores powder have made great progress.