材料科学
化学工程
生物相容性
纳米颗粒
纳米管
碳纳米管
表面改性
作者
Yue Xu,Chenxi Zhao,Xi Zhang,Jingwen Xu,Lingling Yang,Zhechen Zhang,Zhida Gao,Yan-Yan Song
出处
期刊:Nano Research
[Springer Nature]
日期:2021-02-10
卷期号:14 (11): 4046-4055
被引量:2
标识
DOI:10.1007/s12274-021-3338-7
摘要
Infectious diseases caused by bacteria are a global threat to the human health. Here, we propose a solvent “irrigation” technique to endow TiO2 nanotubes (NTs) to precisely modify with functional nanomaterials, and apply them in constructing a near-infrared (NIR) light controlled drug-delivery system for rapid necrosis of bacteria. In this design, the NIR stimuli-responsive functional shell is located on the external tube wall of TiO2 NT; the internal tube wall offers sufficient binding sites for drug loading. Using kanamycin as a model drug, we demonstrate that the reactive oxygen species generated in photocatalysis not only controllably release the loaded drug by scissoring the linked chains, but also effectively compromise bacteria membrane integrity by damaging the cell wall. Benefiting from the damages, antibiotics rapidly enter the bacteria and reach ≥99.9% reduction in Escherichia coli colony within only 2 h. Importantly, such a covalently conjugation-based delivery system can efficiently relieve radical-induced inflammation and cytotoxicity. This study provides an innovative design strategy for engineering delivery systems with tailorable components, enduring stimuli-response by multiple triggers.
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