汤剂
药物数据库
医学
药理学
机制(生物学)
小檗碱
作用机理
小桶
传统医学
计算生物学
化学
体外
药品
生物
生物化学
哲学
基因表达
认识论
转录组
基因
作者
Jie Li,Jinfeng Shi,Xin Nie,Huajuan Jiang,Chaomei Fu,Yao He
出处
期刊:PubMed
日期:2019-02-01
卷期号:44 (3): 559-565
被引量:6
标识
DOI:10.19540/j.cnki.cjcmm.20181119.002
摘要
This paper aimed to predict and explore the mechanism of multiple components, targets and pathways of Siwu decoction for treatment of primary dysmenorrhea, and to establish a network pharmacological model of "compound-target-pathway-disease". According to the active ingredients in Siwu Decoction, Swiss Target Prediction server was used to predict the active component targets based on the reverse pharmacodynamic group matching method, and the primary dysmenorrhea targets approved by FDA were selected by database including DrugBank, OMIM and TTD. According to the enrichment analysis of the target pathways by using KEGG, the Cytoscape software was used to construct the network of "compound-target-pathway-disease" of Siwu Decoction. Network analysis showed that there were 20 active components involved in 114 pathways. And 16 components, 16 target proteins and 24 pathways were related to primary dysmenorrhea. Siwu Decoction may play a role in treating primary dysmenorrhea by acting on protein targets and pathways related to hormone regulation, central analgesia, spasmolysis,inflammation and immunity. This study revealed the potential active compounds and possible mechanism of Siwu Decoction for treatment of primary dysmenorrhea, providing theoretical references for further systematic laboratory experiments on effective compounds and action mechanism of Siwu Decoction.
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