人类白细胞抗原
表位
HLA-A
T细胞受体
抗原
等位基因
免疫学
肽
生物
抗原呈递
病毒学
T细胞
免疫系统
遗传学
基因
生物化学
作者
Shihong Zhang,Jun Li,Hao Cheng,Shuguang Tan,Jianxun Qi,Jinghua Yan,George F. Gao
标识
DOI:10.1016/j.molimm.2011.08.015
摘要
Human leukocyte antigens (HLA) are initially classified by serotyping but recently can be re-grouped by their peptide-presentation characteristics into supertypes. Both HLA-A*0301 and HLA-A*1101 are grouped into A3 supertype. Although a number of cross-presented T cell epitopes of HLA-A*0301 and HLA-A*1101 have been identified, the molecular mechanisms of cross-presentation remain elusive. Herein, the structures of HLA-A*0301 with two HIV-derived immunodominant T cell epitopes were solved and their characteristics in comparison with HLA-A*1101 presenting the same peptides were analyzed. The comparable structures of HLA-A*0301 and HLA-A*1101 with subtle differences illustrate the common modes of cross-presented peptides and the strict HLA-restriction of T cell receptor (TCR)-recognition.
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