Perspectives and challenges for self-assembled layer-by-layer biosensor and biomaterial architectures

This review focusses on challenges for biosensor platforms with self-assembled layer-by-layer (LbL) architectures. Inherent questions involving construction and characterisation of these assemblies, self-assembled monolayers and multilayer LbL structures, are discussed. The preparation of electrochemical biosensors is then addressed in more detail, especially regarding incorporation of nanomaterials. Future perspectives for LbL assemblies for electrochemical biosensing are indicated.