枯草芽孢杆菌
DPPH
单核细胞增生李斯特菌
大肠杆菌
圆二色性
发酵
立体化学
化学
曲霉
真菌
花色曲霉
抗菌活性
酶
微生物学
细菌
生物
生物化学
抗氧化剂
植物
基因
遗传学
作者
Chang-Liang An,Fan-Dong Kong,Qing Ma,Qing-Yi Xie,Jing-Zhe Yuan,Li-Man Zhou,Hao-Fu Dai,Zhifang Yu,You-Xing Zhao
出处
期刊:Marine Drugs
[MDPI AG]
日期:2018-11-26
卷期号:16 (12): 468-468
被引量:15
摘要
Five new compounds named asperpenes A-C (1–3), 12,13-dedihydroversiol (4), and methyl 6-oxo-3,6-dihydro-2H-pyran-4-carboxylate (5), along with 10 known compounds (6–15), were isolated from the fermentation broth of Aspergillus sp. SCS-KFD66 associated with a bivalve mollusk, Sanguinolaria chinensis, collected from Haikou Bay, China. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were unambiguously determined by spectroscopic data, single-crystal X-ray diffraction analysis, and electronic circular dichroism (ECD) spectral analysis, along with quantum ECD calculations. The growth inhibitory activity of the compounds against four pathogenic bacterial (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 6538, Listeria monocytogenes ATCC 1911, and Bacillus subtilis ATCC 6633), their enzyme inhibitory activities against acetylcholinesterase and α-glucosidase, and their DPPH radical scavenging activity were evaluated.
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