刺
干扰素基因刺激剂
癌变
干扰素
信号转导衔接蛋白
信号转导
癌症研究
生物
癌症
免疫学
医学
细胞生物学
先天免疫系统
免疫系统
遗传学
航空航天工程
工程类
作者
Liangmei He,Xiaomei Xiao,Xi Yang,Zixiang Zhang,Longhuo Wu,Zhiping Liu
标识
DOI:10.1016/j.canlet.2017.05.026
摘要
Stimulator of interferon genes (STING) is a DNA sensor and an important cytoplasmic adaptor for other DNA sensors, such as Z-DNA binding protein 1 (DAI), DEAD-box helicase 41 (DDX41), and interferon-γ-inducible protein 16 (IFI16). The activation of STING signaling leads to the production of type I interferons and some other pro-inflammatory cytokines, which are critical for host defense against viral infection. Recent accumulating evidences suggest that STING is also involved in tumor development. However, the role of STING signaling in tumorigenesis is complicated, and a comprehensive review is still lacking. In this paper, we provided an overview of the dual role of STING signaling in tumor development from clinical significance to fundamental mechanisms, as well as its pre-clinical application in cancer therapy.
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