Bleomycin: Untersuchungen zu Synthese und Wirkungsmechanismus

Angewandte ChemieVolume 111, Issue 4 p. 470-500 Aufsatz Bleomycin: Untersuchungen zu Synthese und Wirkungsmechanismus Dale L. Boger, Dale L. Boger [email protected] Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10 550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+ 1) 619-784-7550Search for more papers by this authorHui Cai, Hui Cai Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10 550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+ 1) 619-784-7550Search for more papers by this author Dale L. Boger, Dale L. Boger [email protected] Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10 550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+ 1) 619-784-7550Search for more papers by this authorHui Cai, Hui Cai Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10 550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+ 1) 619-784-7550Search for more papers by this author First published: February 15, 1999 https://doi.org/10.1002/(SICI)1521-3757(19990215)111:4<470::AID-ANGE470>3.0.CO;2-MCitations: 18AboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Stückweise entschlüsselt wurden die Feinheiten der Struktur und Funktion von Bleomycin A2 1, einem klinisch eingesetzten Antitumormittel, das seine biologische Wirkung über die Metallionen- und O2-abhängige, sequenzselektive Spaltung von DNA ausübt. Durch systematisches Modifizieren der Struktur von 1 war es möglich, die subtilen funktionellen Rollen der einzelnen Molekülteile und ihrer Substituenten für Effizienz, Selektivität und Präferenz (Doppelstrang- gegenüber Einzelstrang-DNA) der DNA-Spaltung aufzuklären. References 1 H. Umezawa, K. Maeda, T. Takeuchi, Y. Okami, J. Antibiot. 1966, 19, 200–209. CASPubMedWeb of Science®Google Scholar 2 Bleomycin: Current Status and New Developments (Hrsg.: S. K. Carter, S. T. Crooke, H. Umezawa), Academic Press, New York, 1978. Google Scholar 3 Bleomycin: Chemical, Biochemical and Biological Aspects (Hrsg.: S. M. 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