灰树花
多糖
化学
化学成分
肿瘤坏死因子α
信使核糖核酸
免疫学
生物化学
分子生物学
生物
基因
有机化学
作者
Hui Xu,Jiang-hang Liu,Zhenhua Shen,Ye Fei,Xiangdong Chen
标识
DOI:10.1016/j.carbpol.2010.05.035
摘要
The polysaccharide was extracted from Grifola frondosa mushroom. The chemical composition of G. frondosa polysaccharide was analyzed by the gas chromatography–mass spectroscopy (GC–MS). The G. frondosa polysaccharide was found to consist of glucose, mannose and galactose with a molar ratio of 6.5:1:2.6. The structure of G. frondosa polysaccharide was characterized by infrared (IR) spectrum, 1D NMR and 2D NMR spectroscopy. The absorption peaks of 1415 cm−1, 1154 cm−1 and 851 cm−1 suggested the polysaccharide consisted of pyranoside. It was found that G. frondosa polysaccharide was a heteropolysaccharide consisting of the repeating disaccharide unit. Comparing control rats, G. frondosa polysaccharide treatment markedly enhanced skin TNF-α levels, reduced lgG content, T lymphocytes rate and caspase-3 mRNA expression in group 2 rats. Administration of G. frondosa polysaccharide significantly reduced skin levels of TNF-α, increased lgG content, T lymphocytes rate and caspase-3 mRNA expression in groups 3 and 4 rats. In conclusion, G. frondosa polysaccharides are beneficial for those with skin diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI